Doximity GPT vs GitHub Chat vs Second Brain: Which AI Chat tool is Best in 2025?

All these tools Doximity GPT , GitHub Chat , Second Brain offer flexible pricing models suitable for virtual assistant developers, customer support teams seeking AI-powered solutions to enhance their AI Chat efforts.

Doximity GPT

Starting from
free
Pricing Model:
  • Free - $0

GitHub Chat

Starting from
free

Second Brain

Starting from
$20/month

These AI tools are among the best AI Chat tools available in 2025. For virtual assistant developers, customer support teams, tools like Doximity GPT , GitHub Chat , Second Brain help streamline the AI Chat process by offering AI-powered features.

What is Doximity GPT?

Doximity GPT is a free, HIPAA-compliant AI-powered assistant integrated into the Doximity platform, designed for U.S. clinicians and medical students. It streamlines workflows by automating tasks like generating chart notes, drafting referral or appeal letters, answering clinical questions, and creating patient education materials. Powered by advanced AI models, it offers specialty-specific prompts, multilingual translation, and secure integration with EHR systems, ensuring efficient, accurate, and private task management.

What is GitHub Chat?

GitHub Chat is a free AI-powered Chrome extension launched by Bluera Inc. in 2025, designed to enable real-time conversations with GitHub repositories, files, wikis, or documentation. By integrating directly into GitHub’s interface or via githubchat.ai, it leverages advanced AI to provide instant answers about code, READMEs, or project details, enhancing developer productivity. It is ideal for programmers, open-source contributors, and cybersecurity researchers, it streamlines code comprehension and project navigation. Its intuitive interface, robust features, and ethical design make it essential for open-source contribution, code debugging, and cybersecurity research. By using GitHub Chat responsibly, users can accelerate their workflows, deepen code understanding, and excel in technical projects.

What is Second Brain?

Second Brain is an innovative AI-powered platform designed to revolutionize personal knowledge management, research, and task execution for solopreneurs, developers, and productivity enthusiasts. Unlike traditional note-taking apps like Notion or Obsidian, Second Brain integrates advanced AI chat capabilities, visual boards, and seamless data capture to organize ideas, streamline workflows, and deliver actionable insights from diverse sources like PDFs, videos, and web content. With its Chrome extension and tailored features for niche coding or business strategy, it empowers users to save time and boost efficiency.

Doximity GPT
(4.4/5)
  • Accuracy and Reliability:
    4.5
  • Cost-Efficiency:
    4.5
  • Customization and Flexibility:
    4.5
  • Data Privacy and Security:
    4.5
  • Ease of Use:
    4
  • Functionality and Features:
    4.5
  • Integration Capabilities:
    4
  • Performance and Speed:
    5
  • Support and Resources:
    4.5
GitHub Chat
  • No ratings found!
Second Brain
  • No ratings found!
Doximity GPT
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GitHub Chat
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Second Brain
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Doximity GPT

Pros

Free access for U.S. clinicians and students.

Fast

accurate automation saves time.

Secure with HIPAA-compliant encryption.

Seamless EHR and telehealth integration.

Multilingual patient material creation.

Cons

Restricted to U.S. healthcare professionals.

Minor inaccuracies in complex AI outputs.

Limited customization for outputs.

Manual effort is needed for EHR integration.

Not Enough Data!
Not Enough Data!

If you're looking for other AI Chat tools for virtual assistant developers, customer support teams, you can also explore Buddies AI, DeftGPT, Reply AI Chat, DeepAI, Janitor AI, Arthur AI, SciSpace AI, Type AI, Insighto.ai, Wonderchat AI, Windsurf, Amie, which are highly rated in 2025.

Doximity GPT
  • Doximity
  • United States
GitHub Chat
  • Not Data Available!
Second Brain
  • Not Data Available!